Ontology highlight
ABSTRACT:
SUBMITTER: Monks DA
PROVIDER: S-EPMC2883265 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Monks Douglas Ashley DA Rao Pengcheng P Mo Kaiguo K Johansen Jamie Ann JA Lewis Gareth G Kemp Michael Quentin MQ
Hormones and behavior 20080105 5
Kennedy Disease/Spinal Bulbar Muscular Atrophy (KD/SBMA) is a progressive neurodegenerative disease caused by genetic polyglutamine expansion of the androgen receptor. We have recently found that overexpression of wildtype androgen receptor in skeletal muscle of transgenic mice results in a KD/SBMA phenotype. This surprising result challenges the orthodox view that KD/SBMA requires expression of polyglutamine expanded androgen receptor within motoneurons. Theories relating to the etiology of thi ...[more]