The effect of jasplakinolide on the thermodynamic properties of ADP.BeF(x) bound actin filaments.
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ABSTRACT:
SUBMITTER: Kardos R
PROVIDER: S-EPMC2883441 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
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The effect of jasplakinolide on the thermodynamic properties of ADP.BeF(x) bound actin filaments.
Kardos Roland R Vig Andrea A Orbán József J Hild Gábor G Nyitrai Miklós M Lőrinczy Dénes D
Thermochimica acta 20071001 1-2
The effect of BeF(x) and a natural toxin (jasplakinolide) was examined on the thermal stability of actin filaments by using differential scanning calorimetry. The phosphate analogue beryllium fluoride shifted the melting temperature of actin filaments (67.4 degrees C) to 83.7 degrees C indicating that the filaments were thermodynamically more stable in their complex with ADP.BeF(x). A similar tendency was observed when the jasplakinolide was used in the absence of BeF(x). When both the ADP.BeF(x ...[more]
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