Ontology highlight
ABSTRACT:
SUBMITTER: Ramdas WD
PROVIDER: S-EPMC2883590 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Ramdas Wishal D WD van Koolwijk Leonieke M E LM Ikram M Kamran MK Jansonius Nomdo M NM de Jong Paulus T V M PT Bergen Arthur A B AA Isaacs Aaron A Amin Najaf N Aulchenko Yurii S YS Wolfs Roger C W RC Hofman Albert A Rivadeneira Fernando F Oostra Ben A BA Uitterlinden Andre G AG Hysi Pirro P Hammond Christopher J CJ Lemij Hans G HG Vingerling Johannes R JR Klaver Caroline C W CC van Duijn Cornelia M CM
PLoS genetics 20100610 6
The optic nerve head is involved in many ophthalmic disorders, including common diseases such as myopia and open-angle glaucoma. Two of the most important parameters are the size of the optic disc area and the vertical cup-disc ratio (VCDR). Both are highly heritable but genetically largely undetermined. We performed a meta-analysis of genome-wide association (GWA) data to identify genetic variants associated with optic disc area and VCDR. The gene discovery included 7,360 unrelated individuals ...[more]