Ontology highlight
ABSTRACT:
SUBMITTER: Potter CJ
PROVIDER: S-EPMC2883883 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Potter Christopher J CJ Tasic Bosiljka B Russler Emilie V EV Liang Liang L Luo Liqun L
Cell 20100401 3
We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expression, and QF repression by its repressor QS. Additionally, feeding flies quinic acid can relieve QS repression. The Q system offers many applications, including (1) intersectional ...[more]