Ontology highlight
ABSTRACT:
SUBMITTER: Fabritz L
PROVIDER: S-EPMC2883895 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Fabritz Larissa L Damke Dierk D Emmerich Markus M Kaufmann Susann G SG Theis Kathrin K Blana Andreas A Fortmüller Lisa L Laakmann Sandra S Hermann Sven S Aleynichenko Elena E Steinfurt Johannes J Volkery Daniela D Riemann Burkhard B Kirchhefer Uwe U Franz Michael R MR Breithardt Günter G Carmeliet Edward E Schäfers Michael M Maier Sebastian K G SK Carmeliet Peter P Kirchhof Paulus P
Cardiovascular research 20100128 1
<h4>Aims</h4>Clinical observations in patients with long QT syndrome carrying sodium channel mutations (LQT3) suggest that bradycardia caused by parasympathetic stimulation may provoke torsades de pointes (TdP). Beta-adrenoceptor blockers appear less effective in LQT3 than in other forms of the disease.<h4>Methods and results</h4>We studied effects of autonomic modulation on arrhythmias in vivo and in vitro and quantified sympathetic innervation by autoradiography in heterozygous mice with a kno ...[more]