Ontology highlight
ABSTRACT:
SUBMITTER: Chooi YH
PROVIDER: S-EPMC2884005 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Chooi Yit-Heng YH Cacho Ralph R Tang Yi Y
Chemistry & biology 20100501 5
Penicillium aethiopicum produces two structurally interesting and biologically active polyketides: the tetracycline-like viridicatumtoxin 1 and the classic antifungal agent griseofulvin 2. Here, we report the concurrent discovery of the two corresponding biosynthetic gene clusters (vrt and gsf) by 454 shotgun sequencing. Gene deletions confirmed that two nonreducing PKSs (NRPKSs), vrtA and gsfA, are required for the biosynthesis of 1 and 2, respectively. Both PKSs share similar domain architectu ...[more]