Ontology highlight
ABSTRACT:
SUBMITTER: Findon H
PROVIDER: S-EPMC2884188 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Findon Helen H Calcagno-Pizarelli Ana-Maria AM Martínez José L JL Spielvogel Anja A Markina-Iñarrairaegui Ane A Indrakumar Tanya T Ramos José J Peñalva Miguel A MA Espeso Eduardo A EA Arst Herbert N HN
Fungal genetics and biology : FG & B 20100515 7
In Aspergillus nidulans a combination of null mutations in halA, encoding a protein kinase, and sltA, encoding a zinc-finger transcription factor having no yeast homologues, results in an elevated calcium requirement ('calcium auxotrophy') without impairing net calcium uptake. sltA(-) (+/-halA(-)) mutations result in hypertrophy of the vacuolar system. In halA(-)sltA(-) (and sltA(-)) strains, transcript levels for pmcA and pmcB, encoding vacuolar Ca(2+)-ATPase homologues, are highly elevated, su ...[more]