Ontology highlight
ABSTRACT:
SUBMITTER: Luxenhofer R
PROVIDER: S-EPMC2884201 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Biomaterials 20100326 18
Solubilization of highly hydrophobic drugs with carriers that are non-toxic, non-immunogenic and well-defined remains a major obstacle in pharmaceutical sciences. Well-defined amphiphilic di- and triblock copolymers based on poly(2-oxazolines) were prepared and used for the solubilization of Paclitaxel (PTX) and other water-insoluble drugs. Probing the polymer micelles in water with the fluorescence probe pyrene, an unusual high polar microenvironment of the probe was observed. This coincides wi ...[more]