Ontology highlight
ABSTRACT:
SUBMITTER: Gohler A
PROVIDER: S-EPMC2884264 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Göhler Antonia A André Sabine S Kaltner Herbert H Sauer Markus M Gabius Hans-Joachim HJ Doose Sören S
Biophysical journal 20100601 12
Fluorescence correlation spectroscopy is applied on homologous human lectins (i.e., adhesion/growth-regulatory galectins) to detect influence of ligand binding and presence of the linker peptide in tandem-repeat-type proteins on hydrodynamic properties. Among five tested proteins, lactose binding increased the diffusion constant only in the cases of homodimeric galectin-1 and the linkerless variant of tandem-repeat-type galectin-4. To our knowledge, the close structural similarity among galectin ...[more]