Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach.
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ABSTRACT:
SUBMITTER: Silveira AC
PROVIDER: S-EPMC2884392 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
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Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach.
Silveira Alexandra C AC Morrison Margaux A MA Ji Fei F Xu Haiyan H Reinecke James B JB Adams Scott M SM Arneberg Trevor M TM Janssian Maria M Lee Joo-Eun JE Yuan Yang Y Schaumberg Debra A DA Kotoula Maria G MG Tsironi Evangeline E EE Tsiloulis Aristoteles N AN Chatzoulis Dimitrios Z DZ Miller Joan W JW Kim Ivana K IK Hageman Gregory S GS Farrer Lindsay A LA Haider Neena B NB DeAngelis Margaret M MM
Vision research 20090926 7
To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). Subsequent genotyping of 159 RORA single nucleotide polymorphisms (SNPs) in a family-based cohort, followed by replication in an unrelated case-control cohort, demonstrated that SNPs and haplotypes located in intron 1 were significantly associated with neovascular AMD risk in b ...[more]
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