Ontology highlight
ABSTRACT:
SUBMITTER: Tsai IJ
PROVIDER: S-EPMC2884544 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Tsai Isheng J IJ Otto Thomas D TD Berriman Matthew M
Genome biology 20100413 4
Advances in sequencing technology allow genomes to be sequenced at vastly decreased costs. However, the assembled data frequently are highly fragmented with many gaps. We present a practical approach that uses Illumina sequences to improve draft genome assemblies by aligning sequences against contig ends and performing local assemblies to produce gap-spanning contigs. The continuity of a draft genome can thus be substantially improved, often without the need to generate new data. ...[more]