Ontology highlight
ABSTRACT:
SUBMITTER: Tahirov TH
PROVIDER: S-EPMC2885016 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Tahirov Tahir H TH Babayeva Nigar D ND Varzavand Katayoun K Cooper Jeffrey J JJ Sedore Stanley C SC Price David H DH
Nature 20100601 7299
Regulation of the expression of the human immunodeficiency virus (HIV) genome is accomplished in large part by controlling transcription elongation. The viral protein Tat hijacks the host cell's RNA polymerase II elongation control machinery through interaction with the positive transcription elongation factor, P-TEFb, and directs the factor to promote productive elongation of HIV mRNA. Here we describe the crystal structure of the Tat.P-TEFb complex containing HIV-1 Tat, human Cdk9 (also known ...[more]