Neuronal pentraxins mediate silent synapse conversion in the developing visual system.
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ABSTRACT:
SUBMITTER: Koch SM
PROVIDER: S-EPMC2885289 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Neuronal pentraxins mediate silent synapse conversion in the developing visual system.
Koch Selina M SM Ullian Erik M EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100401 15
Neuronal pentraxins (NPs) are hypothesized to play important roles in the recruitment of AMPA receptors (AMPARs) to immature synapses, yet a physiological role for NPs at nascent synapses in vivo has remained elusive. Here we report that the loss of NP1 and NP2 (NP1/2) leads to a dramatic and specific reduction in AMPAR-mediated transmission at developing visual system synapses. In thalamic slices taken from early postnatal mice (<P10) NP1/2 knock-out (KO) neurons displayed severely reduced AMPA ...[more]
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