Ontology highlight
ABSTRACT:
SUBMITTER: Holmes MC
PROVIDER: S-EPMC2885438 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Holmes Megan C MC Carter Roderick N RN Noble June J Chitnis Shruti S Dutia Amy A Paterson Janice M JM Mullins John J JJ Seckl Jonathan R JR Yau Joyce L W JL
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100501 20
Increased neuronal glucocorticoid exposure may underlie interindividual variation in cognitive function with aging in rodents and humans. 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the regeneration of active glucocorticoids within cells (in brain and other tissues), thus amplifying steroid action. We examined whether 11beta-HSD1 plays a role in the pathogenesis of cognitive deficits associated with aging in male C57BL/6J mice. We show that 11beta-HSD1 levels increase with ...[more]