Molecular photoacoustic tomography with colloidal nanobeacons.
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ABSTRACT:
SUBMITTER: Pan D
PROVIDER: S-EPMC2885454 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Molecular photoacoustic tomography with colloidal nanobeacons.
Pan Dipanjan D Pramanik Manojit M Senpan Angana A Yang Xinmai X Song Kwang H KH Scott Mike J MJ Zhang Huiying H Gaffney Patrick J PJ Wickline Samuel A SA Wang Lihong V LV Lanza Gregory M GM
Angewandte Chemie (International ed. in English) 20090101 23
Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging. ...[more]
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