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Molecular photoacoustic tomography with colloidal nanobeacons.

ABSTRACT: Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

SUBMITTER: Pan D 

PROVIDER: S-EPMC2885454 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Molecular photoacoustic tomography with colloidal nanobeacons.

Pan Dipanjan D   Pramanik Manojit M   Senpan Angana A   Yang Xinmai X   Song Kwang H KH   Scott Mike J MJ   Zhang Huiying H   Gaffney Patrick J PJ   Wickline Samuel A SA   Wang Lihong V LV   Lanza Gregory M GM  

Angewandte Chemie (International ed. in English) 20090101 23

Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging. ...[more]

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