Ontology highlight
ABSTRACT:
SUBMITTER: Anindya R
PROVIDER: S-EPMC2885502 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Anindya Roy R Mari Pierre-Olivier PO Kristensen Ulrik U Kool Hanneke H Giglia-Mari Giuseppina G Giglia-Mari Giuseppina G Mullenders Leon H LH Fousteri Maria M Vermeulen Wim W Egly Jean-Marc JM Svejstrup Jesper Q JQ
Molecular cell 20100601 5
Transcription-coupled nucleotide excision repair (TC-NER) allows RNA polymerase II (RNAPII)-blocking lesions to be rapidly removed from the transcribed strand of active genes. Defective TCR in humans is associated with Cockayne syndrome (CS), typically caused by defects in either CSA or CSB. Here, we show that CSB contains a ubiquitin-binding domain (UBD). Cells expressing UBD-less CSB (CSB(del)) have phenotypes similar to those of cells lacking CSB, but these can be suppressed by appending a he ...[more]