Ontology highlight
ABSTRACT:
SUBMITTER: Aluise CD
PROVIDER: S-EPMC2885559 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Aluise Christopher D CD Robinson Renã A Sowell RA Beckett Tina L TL Murphy M Paul MP Cai Jian J Pierce William M WM Markesbery William R WR Butterfield D Allan DA
Neurobiology of disease 20100423 2
Alzheimer disease (AD) is a neurodegenerative disorder characterized clinically by progressive memory loss and subsequent dementia and neuropathologically by senile plaques, neurofibrillary tangles, and synapse loss. Interestingly, a small percentage of individuals with normal antemortem psychometric scores meet the neuropathological criteria for AD (termed 'preclinical' AD (PCAD)). In this study, inferior parietal lobule (IPL) from PCAD and control subjects was compared for oxidative stress mar ...[more]