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Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.

ABSTRACT: A key step in gene therapy is the efficient transfer of genes in a cell type- and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably functions as a co-receptor for AAV6.

SUBMITTER: Weller ML

PROVIDER: S-EPMC2885716 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.

Weller Melodie L ML Amornphimoltham Panomwat P Schmidt Michael M Wilson Paul A PA Gutkind J Silvio JS Chiorini John A JA

Nature medicine 20100509 6

A key step in gene therapy is the efficient transfer of genes in a cell type- and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably fun ...[more]

PMID: 20473307

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