Ontology highlight
ABSTRACT:
SUBMITTER: Vaidya VS
PROVIDER: S-EPMC2885849 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Nature biotechnology 20100501 5
Kidney toxicity accounts both for the failure of many drug candidates as well as considerable patient morbidity. Whereas histopathology remains the gold standard for nephrotoxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary options for monitoring kidney dysfunction in humans. The transmembrane tubular protein kidney injury molecule-1 (Kim-1) was previously reported to be markedly induced in response to renal injury. Owing to the poor sensitivity and s ...[more]