Erasing sensorimotor memories via PKMzeta inhibition.
Ontology highlight
ABSTRACT:
SUBMITTER: von Kraus LM
PROVIDER: S-EPMC2886075 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Erasing sensorimotor memories via PKMzeta inhibition.
von Kraus Lee Michael LM Sacktor Todd Charlton TC Francis Joseph Thachil JT
PloS one 20100615 6
Sensorimotor cortex has a role in procedural learning. Previous studies suggested that this learning is subserved by long-term potentiation (LTP), which is in turn maintained by the persistently active kinase, protein kinase Mzeta (PKMzeta). Whereas the role of PKMzeta in animal models of declarative knowledge is established, its effect on procedural knowledge is not well understood. Here we show that PKMzeta inhibition, via injection of zeta inhibitory peptide (ZIP) into the rat sensorimotor co ...[more]
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