Ontology highlight
ABSTRACT:
SUBMITTER: Liang Z
PROVIDER: S-EPMC2886130 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Liang Zhiyan Z Chang Sooghee S Youn Min So MS Mohan Chandra C
Molecular immunology 20090624 13
Anti-nuclear antibodies constitute the hallmark of lupus. The NZM2410-derived Sle1 lupus susceptibility interval on murine chromosome 1 breaches tolerance, leading to the emergence of anti-nuclear autoantibodies targeting nucleosomes. However, little is known about the molecular structure of the anti-nucleosome autoantibodies from this genetically simplified mouse model of lupus. In this study, the immunoglobulin heavy chain and light chain sequences of 50 anti-nuclear monoclonal antibodies deri ...[more]