Ontology highlight
ABSTRACT:
SUBMITTER: Doucet CM
PROVIDER: S-EPMC2887351 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Doucet Christine M CM Talamas Jessica A JA Hetzer Martin W MW
Cell 20100601 6
In metazoa, nuclear pore complexes (NPCs) assemble from disassembled precursors into a reforming nuclear envelope (NE) at the end of mitosis and into growing intact NEs during interphase. Here, we show via RNAi-mediated knockdown that ELYS, a nucleoporin critical for the recruitment of the essential Nup107/160 complex to chromatin, is required for NPC assembly at the end of mitosis but not during interphase. Conversely, the transmembrane nucleoporin POM121 is critical for the incorporation of th ...[more]