Unknown

Dataset Information

0

No association between polymorphisms of WNT2 and schizophrenia in a Korean population.

ABSTRACT: BACKGROUND: Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population. METHODS: e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls. RESULTS: Of the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction. CONCLUSION: The present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC2887425 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

No association between polymorphisms of WNT2 and schizophrenia in a Korean population.

Kim Hak-Jae HJ   Park Jin Kyung JK   Kim Su Kang SK   Kang Sung Wook SW   Kim Jong Woo JW   Park Hyun-Kyung HK   Cho Ah-Rang AR   Song Ji Young JY   Chung Joo-Ho JH  

BMC medical genetics 20100524

<h4>Background</h4>Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population.<h4>Methods</h4>e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct seq  ...[more]

Similar Datasets

Unknown Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population.
| S-EPMC2909989 | biostudies-literature
Unknown No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population.
| S-EPMC3013321 | biostudies-literature
Unknown PM447. Association between coding single nucleotide polymorphisms in ADAMTS20 gene and schizophrenia in a Korean population
| S-EPMC5616382 | biostudies-literature
Unknown Association between Unc-51-like autophagy activating kinase 2 gene polymorphisms and schizophrenia in the Korean population.
| S-EPMC8812592 | biostudies-literature
Unknown Association between FAT Gene and Schizophrenia in the Korean Population.
| S-EPMC3766757 | biostudies-literature
Unknown Assessment between Dopamine Receptor D2 (DRD2) Polymorphisms and Schizophrenia in Korean Population.
| S-EPMC3569151 | biostudies-literature
Unknown Association between ABCB1 Polymorphisms and Ischemic Stroke in Korean Population.
| S-EPMC3538181 | biostudies-literature
Unknown Association study between ZFHX3 gene polymorphisms and obesity in Korean population.
| S-EPMC5667630 | biostudies-literature
Unknown Associations between DRDs and schizophrenia in a Korean population: multi-stage association analyses.
| S-EPMC3041937 | biostudies-literature
Unknown Association between Interleukin 31 Receptor A Gene Polymorphism and Schizophrenia in Korean Population.
| S-EPMC2788637 | biostudies-literature