Ontology highlight
ABSTRACT:
SUBMITTER: Okagaki LH
PROVIDER: S-EPMC2887476 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
PLoS pathogens 20100617 6
Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in vivo, producing cells up to 100 microm. These morphological changes in cell size affected pathogenicity via reducing phagocytosis by host mononuclear cells, increasing resistance to oxidative and nitrosative stress, and correlated with reduced penetration of the central nervous system. Cell enlargement was stimulated by coinfecti ...[more]