Ontology highlight
ABSTRACT:
SUBMITTER: Rathinam VA
PROVIDER: S-EPMC2887480 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Nature immunology 20100328 5
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1beta (IL-1beta) and IL-18. AIM2 has been shown to bind DNA and engage the caspase-1-activating adaptor protein ASC to form a caspase-1-activating inflammasome. Using Aim2-deficient mice, we identify a central role for AIM2 in regulating caspase-1-dependent maturation of IL-1beta and IL-18, as well as pyroptosis, in response to synthetic double-stranded DNA. AIM2 was essential for inflammasome activation in respon ...[more]