Ontology highlight
ABSTRACT:
SUBMITTER: Romagnoli R
PROVIDER: S-EPMC2887662 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100501 10
A series of 1-aryl-5-(3',4',5'-trimethoxyphenyl) derivatives and their related 1-(3',4',5'-trimethoxyphenyl)-5-aryl-1,2,4-triazoles, designed as cis-restricted combretastatin analogues, were synthesized and evaluated for antiproliferative activity, inhibitory effects on tubulin polymerization, cell cycle effects, and apoptosis induction. Their activity was greater than, or comparable with, that of the reference compound CA-4. Flow cytometry studies showed that HeLa and Jurkat cells treated with ...[more]