Generation of oxygen gradients with arbitrary shapes in a microfluidic device.
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ABSTRACT:
SUBMITTER: Adler M
PROVIDER: S-EPMC2887752 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Generation of oxygen gradients with arbitrary shapes in a microfluidic device.
Adler Micha M Polinkovsky Mark M Gutierrez Edgar E Groisman Alex A
Lab on a chip 20091127 3
We present a system consisting of a microfluidic device made of gas-permeable polydimethylsiloxane (PDMS) with two layers of microchannels and a computer-controlled multi-channel gas mixer. Concentrations of oxygen in the liquid-filled flow channels of the device are imposed by flowing gas mixtures with desired oxygen concentrations through gas channels directly above the flow channels. Oxygen gradients with different linear, exponential, and non-monotonic shapes are generated in the same liquid ...[more]
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