Ontology highlight
ABSTRACT:
SUBMITTER: Melhus G
PROVIDER: S-EPMC2887935 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Melhus Gunhild G Brorson S H SH Baekkevold E S ES Andersson G G Jemtland R R Olstad O K OK Reinholt F P FP
Calcified tissue international 20100522 1
An experimental rat model was used to test the hypothesis that in osteoporosis (OP) the molecular composition of the extracellular matrix in the fracture callus is disturbed. OP was induced at 10 weeks of age by ovariectomy and a vitamin D(3)-deficient diet, and sham-operated animals fed normal diet served as controls. Three months later a closed tibial fracture was made and stabilized with an intramedullary nail. After 3 and 6 weeks of healing, the animals were killed and the fracture calluses ...[more]