Ontology highlight
ABSTRACT:
SUBMITTER: Liu RQ
PROVIDER: S-EPMC2888410 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Liu Rui-Qin RQ Zhou Qing-Hua QH Ji Shang-Rong SR Zhou Qiang Q Feng Du D Wu Yi Y Sui Sen-Fang SF
The Journal of biological chemistry 20100429 26
beta-Amyloid peptide (Abeta42) is the core protein of amyloid plaque in Alzheimer disease. The intracellular accumulation of Abeta42 in the endosomal/lysosomal system has been under investigation for many years, but the direct link between Abeta42 accumulation and dysfunction of the endosomal/lysosomal system is still largely unknown. Here, we found that both in vitro and in vivo, a major portion of Abeta42 was tightly inserted into and a small portion peripherally associated with the lysosomal ...[more]