Ontology highlight
ABSTRACT:
SUBMITTER: Gupta K
PROVIDER: S-EPMC2888443 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Gupta Kushol K Diamond Tracy T Hwang Young Y Bushman Frederic F Van Duyne Gregory D GD
The Journal of biological chemistry 20100420 26
Integrase (IN) is the catalytic component of the preintegration complex, a large nucleoprotein assembly critical for the integration of the retroviral genome into a host chromosome. Although partial crystal structures of human immunodeficiency virus IN alone and its complex with the integrase binding domain of the host factor PSIP1/lens epithelium-derived growth factor (LEDGF)/p75 are available, many questions remain regarding the properties and structures of LEDGF-bound IN oligomers. Using anal ...[more]