A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children.

ABSTRACT:

Background

Results from trials of intermittent preventive treatment (IPT) in infants and children have shown that IPT provides significant protection against clinical malaria. Sulfadoxine-pyrimethamine (SP) given alone or in combination with other drugs has been used for most IPT programmes. However, SP resistance is increasing in many parts of Africa. Thus, we have investigated whether SP plus AQ, SP plus piperaquine (PQ) and dihydroartemisinin (DHA) plus PQ might be equally safe and effective when used for IPT in children in an area of seasonal transmission.

Methods

During the 2007 malaria transmission season, 1008 Gambian children were individually randomized to receive SP plus amodiaquine (AQ), SP plus piperaquine (PQ) or dihydroartemisinin (DHA) plus PQ at monthly inter

SUBMITTER: Bojang K 

PROVIDER: S-EPMC2888611 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature