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The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients.


ABSTRACT: CONTEXT:The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4. DESIGN:Randomized, double-blind, cross-over intervention study. SETTING:NIH clinical center. PATIENTS:Ten thyroidectomized patients. INTERVENTIONS:Study participants were treated with L-T3 or L-T4 with a target TSH >or= 0.5

SUBMITTER: Celi FS 

PROVIDER: S-EPMC2888764 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients.

Celi Francesco S FS   Zemskova Marina M   Linderman Joyce D JD   Babar Nabeel I NI   Skarulis Monica C MC   Csako Gyorgy G   Wesley Robert R   Costello Rene R   Penzak Scott R SR   Pucino Frank F  

Clinical endocrinology 20100501 5


<h4>Context</h4>The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4.<h4>Design</h4>Randomized, double-blind, cross-over intervention study.<h4>Setting</h4>NIH clinical center.  ...[more]

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