Ontology highlight
ABSTRACT:
SUBMITTER: Rokita SE
PROVIDER: S-EPMC2888766 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Rokita Steven E SE Adler Jennifer M JM McTamney Patrick M PM Watson James A JA
Biochimie 20100216 9
Daily ingestion of iodide alone is not adequate to sustain production of the thyroid hormones, tri- and tetraiodothyronine. Proper maintenance of iodide in vivo also requires its active transport into the thyroid and its salvage from mono- and diiodotyrosine that are formed in excess during hormone biosynthesis. The enzyme iodotyrosine deiodinase responsible for this salvage is unusual in its ability to catalyze a reductive dehalogenation reaction dependent on a flavin cofactor, FMN. Initial cha ...[more]