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Structure and mechanism in salivary proteins from blood-feeding arthropods.

ABSTRACT: The saliva of blood-feeding arthropods contains rich mixtures of ligand binding proteins targeted at inhibiting hemostasis and inflammation in the host. Since blood feeding has evolved many times, different taxonomic groups utilize completely different families of proteins to perform similar tasks. Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mechanistic studies are reviewed.

SUBMITTER: Andersen JF

PROVIDER: S-EPMC2889010 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Structure and mechanism in salivary proteins from blood-feeding arthropods.

Andersen John F JF

Toxicon : official journal of the International Society on Toxinology 20091126 7

The saliva of blood-feeding arthropods contains rich mixtures of ligand binding proteins targeted at inhibiting hemostasis and inflammation in the host. Since blood feeding has evolved many times, different taxonomic groups utilize completely different families of proteins to perform similar tasks. Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mech ...[more]

PMID: 19925819

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