Ontology highlight
ABSTRACT:
SUBMITTER: van Aelst K
PROVIDER: S-EPMC2889075 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
van Aelst Kara K Tóth Júlia J Ramanathan Subramanian P SP Schwarz Friedrich W FW Seidel Ralf R Szczelkun Mark D MD
Proceedings of the National Academy of Sciences of the United States of America 20100430 20
Cleavage of viral DNA by the bacterial Type III Restriction-Modification enzymes requires the ATP-dependent long-range communication between a distant pair of DNA recognition sequences. The classical view is that Type III endonuclease activity is only activated by a pair of asymmetric sites in a specific head-to-head inverted repeat. Based on this assumption and due to the presence of helicase domains in Type III enzymes, various motor-driven DNA translocation models for communication have been ...[more]