Ontology highlight
ABSTRACT:
SUBMITTER: Linton JD
PROVIDER: S-EPMC2889335 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Linton Jonathan D JD Holzhausen Lars C LC Babai Norbert N Song Hongman H Miyagishima Kiyoharu J KJ Stearns George W GW Lindsay Ken K Wei Junhua J Chertov Andrei O AO Peters Theo A TA Caffe Romeo R Pluk Helma H Seeliger Mathias W MW Tanimoto Naoyuki N Fong Kimberly K Bolton Laura L Kuok Denise L T DL Sweet Ian R IR Bartoletti Theodore M TM Radu Roxana A RA Travis Gabriel H GH Zagotta Willam N WN Townes-Anderson Ellen E Parker Ed E Van der Zee Catharina E E M CE Sampath Alapakkam P AP Sokolov Maxim M Thoreson Wallace B WB Hurley James B JB
Proceedings of the National Academy of Sciences of the United States of America 20100505 19
Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy is distributed between cellular compartments in photoreceptors. In avascular retinas, aerobic production of energy occurs only in mitochondria that are located centrally within the photoreceptor. Our findings indicate that metabolic energy flows from these central mitochondria as phosphocreatine toward the photoreceptor's synaptic terminal ...[more]