Ontology highlight
ABSTRACT:
SUBMITTER: Peyrin-Biroulet L
PROVIDER: S-EPMC2889363 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Peyrin-Biroulet Laurent L Beisner Julia J Wang Guoxing G Nuding Sabine S Oommen Sajit Thottathil ST Kelly Denise D Parmentier-Decrucq Erika E Dessein Rodrigue R Merour Emilie E Chavatte Philipe P Grandjean Teddy T Bressenot Aude A Desreumaux Pierre P Colombel Jean-Frédéric JF Desvergne Béatrice B Stange Eduard F EF Wehkamp Jan J Chamaillard Mathias M
Proceedings of the National Academy of Sciences of the United States of America 20100426 19
Crohn's disease (CD), a major form of human inflammatory bowel disease, is characterized by primary immunodeficiencies. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is essential for intestinal homeostasis in response to both dietary- and microbiota-derived signals. Its role in host defense remains unknown, however. We show that PPARgamma functions as an antimicrobial factor by maintaining constitutive epithelial expression of a subset of beta-defensin in the ...[more]