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Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.

ABSTRACT: A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.

SUBMITTER: Graham TG

PROVIDER: S-EPMC2889600 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.

Graham Thomas G W TG Tabei S M Ali SM Dinner Aaron R AR Rebay Ilaria I

Development (Cambridge, England) 20100701 14

A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and dis ...[more]

PMID: 20570936

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