Ontology highlight
ABSTRACT:
SUBMITTER: Graham TG
PROVIDER: S-EPMC2889600 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20100701 14
A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and dis ...[more]