Ontology highlight
ABSTRACT:
SUBMITTER: Dumonceaux J
PROVIDER: S-EPMC2890116 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Dumonceaux Julie J Marie Solenne S Beley Cyriaque C Trollet Capucine C Vignaud Alban A Ferry Arnaud A Butler-Browne Gillian G Garcia Luis L
Molecular therapy : the journal of the American Society of Gene Therapy 20100126 5
Duchenne muscular dystrophy is characterized by muscular atrophy, fibrosis, and fat accumulation. Several groups have demonstrated that in the mdx mouse, the exon-skipping strategy can restore a quasi-dystrophin in almost 100% of the muscle fibers. On the other hand, inhibition of the myostatin pathway in adult mice has been described to enhance muscle growth and improve muscle force. Our aim was to combine these two strategies to evaluate a possible additive effect. We have chosen to inhibit th ...[more]