Ontology highlight
ABSTRACT:
SUBMITTER: Galanis E
PROVIDER: S-EPMC2890216 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Galanis Evanthia E Hartmann Lynn C LC Cliby William A WA Long Harry J HJ Peethambaram Prema P PP Barrette Brigitte A BA Kaur Judith S JS Haluska Paul J PJ Aderca Ileana I Zollman Paula J PJ Sloan Jeff A JA Keeney Gary G Atherton Pamela J PJ Podratz Karl C KC Dowdy Sean C SC Stanhope C Robert CR Wilson Timothy O TO Federspiel Mark J MJ Peng Kah-Whye KW Russell Stephen J SJ
Cancer research 20100126 3
Edmonston vaccine strains of measles virus (MV) have shown significant antitumor activity in preclinical models of ovarian cancer. We engineered MV to express the marker peptide carcinoembryonic antigen (MV-CEA virus) to also permit real-time monitoring of viral gene expression in tumors in the clinical setting. Patients with Taxol and platinum-refractory recurrent ovarian cancer and normal CEA levels were eligible for this phase I trial. Twenty-one patients were treated with MV-CEA i.p. every 4 ...[more]