Ontology highlight
ABSTRACT:
SUBMITTER: Arancio O
PROVIDER: S-EPMC2890287 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Amyloid-beta peptide (Abeta) oligomers are likely to underlie the earliest amnesic changes in Alzheimer's disease through impairment of synaptic function. A recent work from the laboratories of Tae-Wan Kim and Gilbert Di Paolo and colleagues implicates the phosphoinositide signaling pathway in synaptic changes due to elevation of Abeta oligomers. Given that phosphatidylinositol 4,5-bisphosphate (PIP2) is central to many essential processes in neurons including neuronal and synaptic function, red ...[more]