Dataset Information

Maternal family history of diabetes is associated with a reduced risk of cardiovascular disease in women with type 2 diabetes: the Fremantle Diabetes Study.

ABSTRACT:

Objective

To investigate whether parental family history of diabetes influences cardiovascular outcomes in type 2 diabetes.

Research design and methods

We studied 1,294 type 2 diabetic patients (mean age 64.1 years, 51.2% female) recruited to a community-based cohort study from 1993 to 1996 and followed until mid-2006. A data linkage system assessed all-cause and cardiac mortality, incident myocardial infarction, and stroke. Cox proportional hazards modeling was used to determine the influence of maternal or paternal family history on these outcomes.

Results

A maternal family history of diabetes was reported by 20.4% of the cohort, 8.3% reported paternal family history, and 2.0% reported both parents affected. Maternal and paternal family history was associated with earlier age of diabetes onset, and maternal family history was associated with worse glycemic control. For all patients, maternal family history was significantly associated with reduced risk of all-cause mortality and cardiac mortality. When analyzed by sex, maternal family history had no effect on male patients, whereas female patients with diabetic mothers had significantly reduced hazard ratios for death from all causes (0.63 [95% CI 0.41-0.96]; P = 0.033), for death from cardiac causes (0.32 [0.14-0.72]; P = 0.006), and for first myocardial infarction (0.45 [0.26-0.76]; P = 0.003). Paternal family history status was not associated with these outcomes.

Conclusions

A maternal family history of diabetes confers relative protection against cardiovascular disease in female patients but not in male patients with type 2 diabetes. Paternal family history is associated with risks equivalent to those without a family history of diabetes. Some of the clinical heterogeneity of type 2 diabetes is related to maternal transmission effects with differential impact on male and female patients.

SUBMITTER: Bruce DG

PROVIDER: S-EPMC2890344 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Publications

Maternal family history of diabetes is associated with a reduced risk of cardiovascular disease in women with type 2 diabetes: the Fremantle Diabetes Study.

Bruce David G DG Van Minnen Kylie K Davis Wendy A WA Mudhar Jaspreet J Perret Michael M Subawickrama Dayani P DP Venkitachalam Stephanie S Ravine David D Davis Timothy M E TM

Diabetes care 20100405 7

<h4>Objective</h4>To investigate whether parental family history of diabetes influences cardiovascular outcomes in type 2 diabetes.<h4>Research design and methods</h4>We studied 1,294 type 2 diabetic patients (mean age 64.1 years, 51.2% female) recruited to a community-based cohort study from 1993 to 1996 and followed until mid-2006. A data linkage system assessed all-cause and cardiac mortality, incident myocardial infarction, and stroke. Cox proportional hazards modeling was used to determine ...[more]

PMID: 20368412

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Project description:Findings from previous studies examining the association between gestational diabetes mellitus (GDM) and subsequent risk of cardiovascular disease (CVD) have been inconsistent and inconclusive. We aimed to examine the associations of a previous history of GDM with risk of CVD and status of cardiovascular risk factors in a nationwide population-based study in the United States.This study included 8,127 parous women aged 20?years or older in the 2007-2014 cycles of the National Health and Nutrition Examination Survey in the United States. The exposure was self-reported diagnostic history of GDM and the outcomes were self-reported diagnostic history of CVD and measurements of cardiovascular risk factors, including blood pressure and blood lipids. Regression models with sample weights were used to examine the associations of GDM with CVD and cardiovascular risk factors.Among women with a history of both GDM and CVD, CVD was diagnosed on average 22.9?years after the diagnosis of GDM. After adjustment for demographic, socioeconomic, and lifestyle factors, a history of GDM was associated with 63% higher odds of CVD [odds ratio (OR) 1.63, 95% confidence interval (CI) 1.02, 2.62, p-value?=?0.04]. Further adjustment for body mass index (BMI) modestly attenuated the association (OR 1.52, 95% CI 0.95, 2.44, p-value?=?0.08). A history of GDM was significantly associated with lower serum level of HDL-cholesterol (adjusted ?-coefficient -3.33, 95% CI -5.17, -1.50, p-value???0.001), but not associated with total cholesterol, LDL-cholesterol, triglycerides, or systolic or diastolic blood pressure. Similarly, the association between a history of GDM and HDL cholesterol was attenuated after additional adjustment for BMI (adjusted ?-coefficient -1.68, 95% CI -3.38, 0.03, p-value?=?0.54).Women with a previous history of GDM have significantly higher risk for developing CVD and lower serum level of HDL cholesterol, compared to women without a history of GDM. The associations may be explained, at least partly, by BMI.

Dataset Information

Maternal family history of diabetes is associated with a reduced risk of cardiovascular disease in women with type 2 diabetes: the Fremantle Diabetes Study.

Objective

Research design and methods

Results

Conclusions

Publications

Maternal family history of diabetes is associated with a reduced risk of cardiovascular disease in women with type 2 diabetes: the Fremantle Diabetes Study.

Similar Datasets

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