Characterization of the role of the tumor marker Nup88 in mitosis.
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ABSTRACT:
SUBMITTER: Hashizume C
PROVIDER: S-EPMC2890605 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Characterization of the role of the tumor marker Nup88 in mitosis.
Hashizume Chieko C Nakano Hiroshi H Yoshida Kimihisa K Wong Richard W RW
Molecular cancer 20100524
Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup). Our recent studies indicated that the nucleoporins Rae1 and Tpr play critical roles in maintaining the spindle bipolarity during cell division. In the present study, we found that another nucleoporin, Nup88, was localized on the spindles together with Nup214 during mitosis. Nup88 expression is linked to the p ...[more]
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