Ontology highlight
ABSTRACT:
SUBMITTER: Chen HC
PROVIDER: S-EPMC2891132 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Chen Hui-Chen HC Reich Nancy C NC
Journal of immunology (Baltimore, Md. : 1950) 20100524 1
The STAT6 transcription factor is essential for the development of protective immunity; however, the consequences of its activity can also contribute to the pathogenesis of autoimmune disease. Tyrosine phosphorylation is known to activate STAT6 in response to cytokine stimulation, but there is a gap in our understanding of the mechanisms by which it enters the nucleus. In this study, live cell imaging was used in conjunction with photobleaching techniques to demonstrate the continual nuclear imp ...[more]