Rational antibody-based HIV-1 vaccine design: current approaches and future directions.
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ABSTRACT:
SUBMITTER: Walker LM
PROVIDER: S-EPMC2891291 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Rational antibody-based HIV-1 vaccine design: current approaches and future directions.
Walker Laura M LM Burton Dennis R DR
Current opinion in immunology 20100317 3
Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologi ...[more]
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