Bioinformatic Identification of Novel Methyltransferases.
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ABSTRACT:
SUBMITTER: Petrossian T
PROVIDER: S-EPMC2891558 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Bioinformatic Identification of Novel Methyltransferases.
Petrossian Tanya T Clarke Steven S
Epigenomics 20091001 1
Methylation of DNA, protein, and even RNA species are integral processes in epigenesis. Enzymes that catalyze these reactions using the donor S-adenosylmethionine fall into several structurally distinct classes. The members in each class share sequence similarity that can be used to identify additional methyltransferases. Here, we characterize these classes and in silico approaches to infer protein function. Computational methods such as hidden Markov model profiling and the Multiple Motif Scann ...[more]
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