Ontology highlight
ABSTRACT:
SUBMITTER: Litzinger MT
PROVIDER: S-EPMC2891581 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Litzinger Mary T MT Foon Kenneth A KA Tsang Kwong-Yok KY Schlom Jeffrey J Palena Claudia C
Leukemia research 20100131 10
Adenoviral transduction with CD40L and poxviral transduction with B7-1, ICAM-1, and LFA-3 (TRICOM) have been used to enhance the antigen-presenting capacity of chronic lymphocytic leukemia (CLL) cells. This study compares the same vector (modified vaccinia virus strain Ankara (MVA)) encoding CD40L or TRICOM for its ability to enhance the immunogenicity of CLL cells. CLL cells from some patients showed differential responses to each vector in terms of induction of autologous T-cell responses. Thi ...[more]