Actin-aggregating cucurbitacins from Physocarpus capitatus.
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ABSTRACT:
SUBMITTER: Maloney KN
PROVIDER: S-EPMC2891781 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Actin-aggregating cucurbitacins from Physocarpus capitatus.
Maloney Katherine N KN Fujita Masaki M Eggert Ulrike S US Schroeder Frank C FC Field Christine M CM Mitchison Timothy J TJ Clardy Jon J
Journal of natural products 20081029 11
Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division. ...[more]
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