Ontology highlight
ABSTRACT:
SUBMITTER: Braskie MN
PROVIDER: S-EPMC2891885 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Braskie Meredith N MN Klunder Andrea D AD Hayashi Kiralee M KM Protas Hillary H Kepe Vladimir V Miller Karen J KJ Huang S-C SC Barrio Jorge R JR Ercoli Linda M LM Siddarth Prabha P Satyamurthy Nagichettiar N Liu Jie J Toga Arthur W AW Bookheimer Susan Y SY Small Gary W GW Thompson Paul M PM
Neurobiology of aging 20081111 10
Amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer's disease (AD), begin accumulating in the healthy human brain decades before clinical dementia symptoms can be detected. There is great interest in how this pathology spreads in the living brain and its association with cognitive deterioration. Using MRI-derived cortical surface models and four-dimensional animation techniques, we related cognitive ability to positron emission tomography (PET) signal from 2- ...[more]