A comparison of deterministic and stochastic simulations of neuronal vesicle release models.
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ABSTRACT:
SUBMITTER: Modchang C
PROVIDER: S-EPMC2892017 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
A comparison of deterministic and stochastic simulations of neuronal vesicle release models.
Modchang Charin C Nadkarni Suhita S Bartol Thomas M TM Triampo Wannapong W Sejnowski Terrence J TJ Levine Herbert H Rappel Wouter-Jan WJ
Physical biology 20100526 2
We study the calcium-induced vesicle release into the synaptic cleft using a deterministic algorithm and MCell, a Monte Carlo algorithm that tracks individual molecules. We compare the average vesicle release probability obtained using both algorithms and investigate the effect of the three main sources of noise: diffusion, sensor kinetics and fluctuations from the voltage-dependent calcium channels (VDCCs). We find that the stochastic opening kinetics of the VDCCs are the main contributors to d ...[more]
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